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Electroacupuncture exerts analgesic effect by influencing miR-21-5p/Smad7, thereby further regulating the TGF-β/Smads pathway in rats with CPSP. A - B . WB expression of TGF-β1, p-Smad2 and p-Smad3 in the VPL (ventral posterolateral) region of rat brain tissue in different groups ( n = 3). C . Diagram of the mechanism of electroacupuncture exerts analgesic effect on CPSP

Journal: The Journal of Headache and Pain

Article Title: Electroacupuncture alleviates central post-stroke pain in rats by modulating miR-21-5p/TGF-β/Smads pathway

doi: 10.1186/s10194-025-02247-1

Figure Lengend Snippet: Electroacupuncture exerts analgesic effect by influencing miR-21-5p/Smad7, thereby further regulating the TGF-β/Smads pathway in rats with CPSP. A - B . WB expression of TGF-β1, p-Smad2 and p-Smad3 in the VPL (ventral posterolateral) region of rat brain tissue in different groups ( n = 3). C . Diagram of the mechanism of electroacupuncture exerts analgesic effect on CPSP

Article Snippet: Rat brain tissue sections, previously embedded in paraffin, underwent incubation with GFAP (1:250, Abcam, UK), IBA1 (1:250, CST, USA), and Smad7 (1:250, Proteintech, China) antibodies.

Techniques: Expressing